Zachepa O. The role of hepatic dysfunction in the course of combined abdominal and thoracic trauma in the early period of traumatic disease and their correction

Object - the course of combined thoracoabdominal injury in the early manifestations of traumatic illness; the aim is to find out the peculiarities of the formation of liver dysfunction under the conditions of a combination of penetrating chest injury and blunt abdominal trauma in rats in the early period of traumatic disease and to evaluate the effectiveness of its correction with thiotriazoline; methods - experimental, functional, biochemical, morphological, mathematical and statistical; results - pathogenetic features of liver damage in the period of early manifestations of traumatic disease after penetrating chest injury, blunt abdominal trauma and their combination, proved the effectiveness of thiotriazoline in reducing the manifestations of liver dysfunction; found that the pathogenesis of the period of early manifestations of traumatic disease is the sum of the prooxidant effects of isolated chest trauma and isolated abdominal trauma, accompanied by a greater increase in lipid peroxidation, reduced activity of superoxide symutase and catalase in the liver in particular compared with trauma; it is shown that under the conditions of modeling of the combined trauma of a thorax and a stomach in an organism of experimental animals in the early period processes of cytolysis amplify that from 1 to 7 days of the posttraumatic period is shown by gradual increase in activity in blood serum of alanine and aspartate aminotransferases. the impact of each injury, in particular at all times of observation; It was found that under conditions of combined trauma to the chest and abdomen, compared with animals of the control group and isolated injuries, significantly impaired biliary and biliary function of the liver, manifested by decreased synthesis of cholates from 1 to 7 days posttraumatic period, increased cholesterol and reduced cholate- cholesterol ratio from 1 day of the post-traumatic period, as well as a decrease in the rate of bile excretion and the rate of excretion of the main components of bile; It is proved that the use of thiotriazoline for 7 days of the post-traumatic period has a positive effect on the course of combined thoracoabdominal trauma, which is manifested by decreased lipid peroxidation activity, increased antioxidant protection, reduced cytolysis, improved morphofunction of the liver.