1. Objects – reactions [2+3]-cyclocondensation, aminolysis, hydrazinolysis, thionization, Knevenagel reaction and multicomponent chemical processes; aim –study of methods of synthesis and some transformations of aminomethylenethiazolidinones, screening of pharmacological activity, selection of leading compounds to establish the dependence «structure - activity»; methods – organic synthesis, NMR spectroscopy, chromato mass spectrometry, elemental analysis, X-ray diffraction analysis, in vitro and in vivo pharmacological studies, COMPARE and SAR analysis, molecular docking; novelty – developed methods for the synthesis of undescribed in the literature derivatives of 5-aminomethylenethiazolidinones as compounds with predicted biological activity; it was found that 5-ethoxy-methylenethiazolidinones easily interact with such nucleophiles as functionalized primary and secondary aromatic and aliphatic amines in the environment of alcohols with the formation of the corresponding enamines; when studying the aminolysis reaction of 5-ethoxymethylenethiazolidinones, the possibility of replacing the ethoxy group with an amino group by using as a "donor" ammonia ammonium bicarbonate; it was found that the use of 3,5-diarylpyrazolines as an amino component in interaction with 5-ethoxymethylenethiazolidinones is an effective approach to the design of pyrazoline-thiazolidinone conjugates in the context of the "hybrid-pharmacophore" approach in the creation of new "drug-like molecules"; found that the interaction of (2H-[1,2,4]-triazol-3-ylsulfanyl)-acetic acid with triethylorthoformate in acetic anhydride is a two-step process involving heterocyclization and condensation reactions on the methylene active group to form 5-ethoxymethylene [3-b][1,2,4]triazol-6-one; shown that 5-ethoxymethylene-2-(4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropionic acid ethyl ester and 5-ethoxymethylenethiazolo [3,2-b][1,2,4]triazole -6-one easily interacts with aliphatic, aromatic and heterocyclic amines, as well as ammonium bicarbonate in the environment of alcohols with the formation of the corresponding enamines; it was found that the interaction of 5-ethoxymethylenethiazolo [3,2-b][1,2,4]triazol-6-one with hydrazine hydrate in ethanol passes with the recycling of the intermediate enamine and the formation of hard-to-reach 4-2H-[1,2,4]triazol-5-ylsulfanyl)-1,2-dihydropyrazol-3-one; results – developed methods of synthesis and conversion of 5-aminomethylenethiazolidinones and their functional derivatives; selected new highly effective compounds with antistaphylococcal, anticandidal, antitumor, antitrypanosomal and anti-inflammatory activity, which are recommended for further in-depth research; established a number of patterns in the context of the dependence "structure - activity" and prognostic characteristics for the molecular design of potential "drug-like" molecules; introduced – into the educational process of higher educational institutions; branch – pharmacy
