Hariyan S. The role of ischemia - reperfusion of limbs in the pathogenesis of osteogenesis disorders in case of severe combined abdomino-skeletal trauma and massive blood loss

The dissertation features the pathogenesis of osteogenesis disorders with combined abdominal and skeletal trauma, massive blood loss, and limb ischemia - reperfusion. For the first time, a comparative analysis of a number of indicators responsible for prooxidant, antioxidant, biochemical and morphological disorders in serum and bone tissue in the early and late post-traumatic period was conducted. It is found that ischemia-reperfusion of the extremities causes a decrease in bone mineral density, which is manifested by a significant decrease in calcium and phosphorus in bone tissue. The morphological changes of the hip and knee joints were analyzed after 21 days of experimental trauma and the presence of reactive changes characteristic of inflammatory processes in the joints was revealed. Combined abdominal and skeletal trauma complicated by massive blood loss and its combination with ischemia-reperfusion of the extremities causes significant disorders of bone metabolism in the late post-traumatic period. Comparative analysis of morphological changes after 21 days of experimental trauma revealed the presence of hip and knee joints reactive changes characteristic of inflammatory processes of large joints, namely: pronounced changes in hyaline cartilage of the metaepiphyseal plate of the joints, edema of connective tissue, violation of the orderly location of the insert plates of the compact bone, significant vascular disorders in the form of arteries with thickening, edema of the adventitial lining of the vessels was noted.