In the scientific work at the modern methodological level, there has been improved and developed a new direction of infertility treatment in patients with polycystic ovary syndrome, which includes vitamin complex with inositol and vitamin D3 in pregravid preparation of controlled ovarian stimulation with recombinant gonadotropin of prolong action corifollitropin-alfa “Elonva” in protocols with gonadotropin-releasing hormone antagonists and double administration of the gonadotropin-releasing hormone agonist trigger “Diphereline” (at a dose of 0,2 mg/ml and after 12 hours in addition at a dose of 0,1 mg/ml), which affects oocyte maturation and fertilization process. Hormonal imbalance in women with infertility on the background of polycystic ovary syndrome, in particular, increased concentrations of anti-Mullerian and luteinizing hormones, estradiol and testosterone, decreased concentrations of follicle-stimulating hormone, with the concentration of hormones of the reproductive system, has been detected. It has been shown that the use of vitamin complex with inositol and vitamin D3 by women with infertility and polycystic ovary syndrome for 8 weeks reduces the concentration of androgens and increases the concentration of oestrogen, indicating normalization of ovulation, while on the day of ovulation trigger the concentration of estradiol was 1,14 times lower, and concentration of progesterone, respectively, 1,50 times lower than in the traditional scheme of controlled ovarian stimulation. It has been confirmed that in polycystic ovary syndrome, the most important parameters for assessing ovarian reserve are the basal concentration of anti-Mullerian hormone, the level of follicle-stimulating hormone and the ratio of luteinizing hormone / follicle-stimulating hormone, as well the number of antral follicles and the volume of the ovaries at ultrasound examination. A comparative characterization was performed and it was found out that the use of controlled ovarian stimulation with the administration of gonadotropin-releasing hormone antagonists and gonadotropin-releasing hormone agonist trigger “Diphereline” according to the scheme: 0,2 mg/ml, and after 12 hours – 0,1 mg/ml, can significantly reduce the risk of ovarian hyperstimulation syndrome (1,6 % of women), whereas with controlled ovarian stimulation according to a long protocol, it is found in 92,00 % of women. Almost the same effectiveness of controlled ovarian stimulation in women with infertility and polycystic ovary syndrome according to the long and modified short protocols was proved, which is confirmed by the number of obtained mature oocytes. It has been compared the relative number of pregnancies, achieved in women with infertility and polycystic ovary syndrome, who underwent controlled ovarian stimulation according to a modified short protocol (55,56 %) and a long protocol with fresh embryo transfer (40,91 %), that explains pregravid training and optimized protocols of controlled ovarian stimulation with gonadotropin-releasing hormone antagonists and recombinant corifollitropin-alfa gonadotropin by the method of delayed embryo cryotransfer.
