Objects of research – herb, leaves, stems, rhizomes with roots of Sanicula europaea L., extracts, individual biologically active substances, plant growth conditions; aim – pharmacognostic study of Sanicula europaea L. and establishing the possibility of developing the drugs based on biologically active substances of the studied raw materials; methods – morphological, anatomical and organoleptic, resource studies, physical, physico-chemical, chemical, technological, toxicological, pharmacological, microbiological, statistical; novelty – the presence of the main groups of biologically active substances was established; the content of oxidizable phenols, the sum of polyphenols, tannins, flavonoids, triterpene saponins, hydroxycinnamic and organic acids, including ascorbic acid, vitamin K1 was studied; for the first time the content of fractions of water-soluble polysaccharides, pectic substances, hemicellulose A and hemicellulose B in herb and rhizomes with roots of Sanicula europaea L. were isolated and established; their monomeric composition was established; for the first time 10 phenolic compounds were identified in Sanicula europaea L.herb: 6 metabolites of tannin – gallocatechin, catechin, epicatechin, catechin gallate, epicatechin gallate, ellagic acid; 2 flavonoids – kaempferol, apigenin; coumarin; ferulic acid; 3 steroids – β-sitosterol, stigmastan-3,5-diene, stigmasterol; in the essential oil 13 components of volatile compounds – β-patchulene, β-cedrene, trans-α-bergamotene, β-helmiscapen, α-cadinene, α-murulene, bisabolen, (-)-calamenene, caryophyllene oxide, 1-methyl-6-methylenebicyclo[3.2.0] heptane, heptacosane, 4,11-selinadiene, hexahydrofarnesyl acetone; fatty acids – palmitoleic, palmitic, linoleic, linolenic, stearic, behenic, tricosanic, lignoceric, cerotic; amino acids – threonine, valine, methionine, isoleucine, leucine, phenylalanine, lysine, histidine, aspartic and glutamic acid, serine, proline, cystine, glycine, alanine, tyrosine, arginine; 11 phenolic compounds were detected for the first time in rhizomes with roots: 7 metabolites of tannin – gallic and ellagic acids, gallocatechin, epigallocatechin, catechin, epicatechin, epicatechin gallate; apigenin; coumarin; 2 hydroxycinnamic acids – caffeic, ferulic; amino acids – threonine, valine, methionine, isoleucine, leucine, phenylalanine, lysine, histidine, aspartic and glutamic acids, serine, proline, cystine, glycine, alanine, tyrosine, arginine; for the first time by the method of liquid-liquid fractionation, chromatography on silica gel columns, preparative chromatography on paper, fractional crystallization from the Sanicula europaea L. herb, 6 hydroxycinnamic acids (caffeic, chlorogenic, neochlorogenic, rosemary, ferulic, p-coumaric); from the underground organs of the Sanicula europaea L. – 5 hydroxycinnamic acids (caffeic, chlorogenic, neochlorogenic, rosemary, ferulic); for the first time the elemental composition of herb and rhizomes with roots of Sanicula europaea L. was studied; for the first time morphological and anatomical diagnostic signs of European undergrowth raw material, numerical indicators of Sanicula europaea L. herb, which were used for identification and standardization of plant raw materials, were established; the places of plant growth on the territory of Ivano-Frankivsk and Chernivtsi regions were revealed; for the first time the stocks of raw materials of Sanicula europaea L. in Precarpathian region were determined; on the basis of the conducted phenological and agrotechnical researches the possibility of cultivation of Sanicula europaea L. in the conditions of Precarpathian region is established; the novelty of the research was confirmed and protected by the patent of Ukraine for a utility model № 132069 "Method of obtaining the extract from the herb of Sanicula europaea L. with hemostatic activity"; results – the obtained results of pharmacognostic research indicate the possibility of using the raw material of Sanicula europaea L. as a promising source of biologically active substances with hemostatic and wound-healing properties; the parameters of biologically active substances’ extraction were investigated, 4 dry extracts from Sanicula europaea L. raw materials were obtained; the possibility of using extracts of Sanicula europaea L. herb as medicines with hemostatic, wound-healing, anti-inflammatory and antimicrobial action was proved; the projects of methods of quality control “Sanicula europaea L. herb”, “Dry extract from Sanicula europaea L. herb” and “Instruction for harvesting and drying of Sanicula europaea L. herb” were developed; introduced – based on the materials of the dissertation the monograph "Prospects for the use of Sanicula europea L. and Astrantia major L. in medicine and pharmacy" was published and along with other research results it was introduced into the educational process of higher education establishments and in the practical work ; branch – pharmacy.
