Tkachenko V. Morphofunctional features of the thymus, the adrenal glands and the levels of rats’ blood on the background of the mechanical wound in case of chronic tobacco intoxication of their parents

It has been experimentally proven that passive smoking by parents leads to a violation of the immune endocrine system, namely the morphofunctional state of the thymus and adrenal glands against the background of a mechanical wound. Against the background of the course of the first phase of the wound process, a decrease in epithelial cells and signs of destruction of the nuclear apparatus in the thymus medulla of the offspring were revealed. In rat pups of the experimental groups, signs of an increased morphofunctional state of the fascicular zone of the adrenal glands and a multidirectional level of corticosterone were established, which led to inhibition of reactivity, which negatively affected the normal course of wound healing. The course of the early process in offspring depended on the content of nicotine and tar in cigarettes and on the smoking model in a married couple (only the father or both parents smoked). It was shown that in the descendants of whose parents were smoked with filter cigarettes, the wound process was characterized by an increased in secondary alteration around the damaged area and the development of phlegmon. In the offspring, whose parents were smoked with cigarettes without a filter, during the wound process, areas with purulent infiltration and large necrotic changes were noted. The offspring of the experimental groups, an increase in the number of leukocytes in the blood was revealed, a decrease or increase in the content of total protein, seromucoids and protein fractions. Changes in blood counts were more pronounced in the offspring-rat pups whose parents were smoked with non-filter cigarettes. It was found that chronic intoxication with tobacco smoke from parents leads to a decrease in the survival index of offspring and to a reduction in the timing of their physical development, especially in the group where the male and female were smoked.