Vaskiv O. Prediction of the development and optimization of diagnostics of perinatal pathology in pregnant women with gestational hypertension

On the basis of dissertation study, the risk factors for the development of perinatal pathology in gestational hypertension were established and the features of the course of pregnancy against the background of gestational hypertension were determined. It has been proven that the presence of hypertensive disorders during pregnancy, even of a mild degree, significantly increases the risk of adverse obstetric and perinatal consequences of pregnancy. Scientific data on pathological changes in the vasoregulatory properties of the endothelium in gestational hypertension have been supplemented on the basis of a reliable increase in the serum level of endothelin-1 by 83.5 % and the ET-1/SNP ratio by 86.0 %. The conducted research deepens the understanding of the mechanisms of development of endothelial dysfunction in pregnant women with gestational hypertension. Determination of endothelin-1, C-natriuretic peptide and their ratio for the diagnosis of endothelial dysfunction in gestational hypertension is proposed. The prognostic risk models of the development of obstetric and perinatal consequences of pregnancy were developed from the standpoint of the influence of gestational hypertensive disorders, which with high sensitivity and specificity allow predicting adverse obstetric consequences of pregnancy in women with gestational hypertensive disorders. A treatment scheme for microcirculation disorders in the fetoplacental zone in this pathology was developed using a complex of infusion drugs of pentoxifylline, a solution containing arginine hydrochloride and levocarnitine, and reosorbilact in pregnant women with gestational hypertension against the background of basic antihypertensive therapy, which significantly reduces the frequency of obstetric and perinatal complications pregnancy in women with this pathology.