Kovalenko O. The innate and acquired forms behavior of rats with different degree of alcoholic motivation

The sensitivity of innate and acquired rat’s behavior, level of oxidative processes in the brain tissue and blood lipids to ethanol at different combinations of alcohol consumption and learning in rats were investigated. Also determined the relationship of behavioral characteristics with the processes of the emergence of alcohol dependence in rats. It has been established that chronic alcoholism reduces the learning speed and increases the number of errors, while training prior to the onset of alcoholism mitigates the negative impact of ethanol on memory processes. Additionally, rats with high alcohol motivation exhibit a higher learning speed and fewer errors. Chronic ethanol consumption after training in the radial maze inhibited formation of conditioned reaction in animals with low alcoholic motivation, compared with rats that preferred alcohol. It has been demonstrated that chronic alcoholization reduces the level of anxiety-neurotic reactions in rats with high alcohol motivation, stimulating locomotor and exploratory activity while decreasing emotional reactions in innate behavior. In contrast, in rats with low alcohol motivation, alcoholism increases the level of anxiety. It was found that changes in cognitive-behavioral activity after chronic ethanol consumption correlate with changes in interhemispheric asymmetry of the brain. Changes are shown in the inhibition processes of information processing in the right hemisphere during alcoholization. Inversion of motor asymmetry is more pronounced and sustained in animals with low learning ability in the radial maze. The propensity to alcohol dependence correlates with the level of motor asymmetry, as reflected by the predominance of reliable profiles of the left motor symptoms in rats with high alcohol motivation. Indication's relationship between the level of behavioral activity, asymmetry and the level of TBK-active products in brain tissue of rats in various schemes combining alcoholization processes and training. Chronic alcoholism leads to an increase in blood lipid concentration in rats. Moreover, in rats with low alcohol motivation, lipid levels in the blood after the completion of alcoholism are higher compared to other rats.