Goldobina O. The endothelial injury characteristic features during the development of experimental Monkeberg's medial calcific sclerosis.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0499U000435

Thesis Registration Form

0499U000435.pdf

Applicant for

Specialization

  • 14.03.04 - Патологічна фізіологія

24-02-1999

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

The transmission electron microscopy, the changes in endothelial vascular ultrastructure which can be either sensitive or insensitive to medial calcific sclerosis are explored.It was established that acute massive injury of endothelium had been present in aorta on the first day after single-action adrenalinemia. Therefore, acute massive endothelial injury is a precondition of the hyperconstriction and necrosis of aortal SMCs in the condition of hyperadrenalinemia and may be considered as an important mechanism in pathogenesis of "adrenalinal" aorta mediacalcinosis.

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