Sokolenko V. T cells surface markers expression of lymphocytes of people, injured by effect of accident factors of CAS.

Thesis for a candidates degree of biological sciences by speciality 03.00.13 - Physiology of a human being and animals. - The Institute of Physiology of Academy of Sciences of Ukraine, named after O.O. Bogomolets, Kyiv, 1998. The dissertation deals with research of cellular immunity state of people injured by the effect of atomic accident in Chornobyl in 7-10 years later. The immunofluorescent method analysis of T cells surface markers expression was used. Data obtained show that there was revealed T cells surface antygen modification of people, injured in acute and chronical exposure by low doses of the ionizing radiation comparatively with control. Such state are manifested in rated decrease of CD3+ and CD5+ mature T cells, immuno-regulating index (CD4+/CD8+ ratio), CD3-16+56+ natural killer cells and rated increase cells with CD4+CD25+ and CD4+HLA-DR+ phenotype. The revealed changes correction by means of normobaric hypoxia and mineral-, polyvitaminotherapy seances were observed. The results of thew ork obtained may be of theoretical basis for immunocorrection of people injured to effect by accident factors of CAS.