Isayeva O. The participation of voltage-activated calcium channels in inhibitory synaptic transmission at the culture of hippocampal neurons.

The dissertation is devoted to investigation of electrophysiological and pharmacological properties of inhibitory postsynaptic currents of developing rat hippocampal neurons in vitro and the participation of voltage-activated calcium channels in inhibitory synaptic transmission. The obtained results indicated that enlargement of cultivating term caused an increase of the number of synaptic contacts and complication of the structure of neuronal net whereas synaptic transmission in individual neurons pair didn't change. It was shown, that inhibitory synaptic transmission in hippocampal neurons in vitro was mediated by N-,P-/Q-types of calcium channels ,channel sensitive to high concentration of nifedipine and calcium channels, which have not specific blockers.