Topol'nik Y. Mechanisms of action of vitamine derivatives of GABA on the inhibitory postsynaptic potentials in neocortical neurons

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0499U003186

Thesis Registration Form

0499U003186.pdf

Applicant for

Specialization

  • 03.00.13 - Фізіологія людини і тварин

30-11-1999

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

The dissertation is devoted to the investigation of neurophysiological mechanisms of action of the vitamine derivatives of GABA - panthogam, pycamilon and GABA-ascorbinate. The influence of these compounds on the postsynaptic reactions of the normal and epileptic neocortical neurons was studied. Doses that induce different effects on the cortical inhibition are determined. Mechanisms of action of these drugs on the GAВA-receptor-channel complex are discussed. The results of the work have found clinical applications in psychoneurology and psychopharmacology.

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