Yanchij R. Mechanisms of the antibody-induced calcium homeostasis modulation in the cell-targets.

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0501U000307

Thesis Registration Form

0501U000307.pdf

Applicant for

Specialization

  • 03.00.13 - Фізіологія людини і тварин

18-09-2001

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

The work is devoted to the investigation of the antibody-induced calcium homeostasis modulation in cardiomyocytes and oocytes, involving membrane mechanisms of Ca2+ influxes to the cell-target and mechanisms of calcium release from intracellular pools of SPR. It was the first shown that antibody-induced mobilization of the Ca2+, inhibition of the transport ATPase, distortion of the Na+-Ca2+ exchanger, generation of the LP products and eicosanoids are the main factors for intracellular calcium concentration regulation in cell-targets. Developed new technology for the receiving and studying of the use of optimal doses of anti-ovarian serums (AOCS-c and AOCS-s) for reproductive system stimulation.

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Files

yanchiy.doc

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