Kotsyumbas I. System of toxicological control of agents for protecting animals and fodder additives

The dissertation is dedicated to the study and development of the systems of toxicological control of the fodder additives and agents for protecting animals The scientifically proved system of carrying out toxicological control of agents for protecting animals and fodder additives including the study of the subject of the definition of acute and chronic toxicity, cumulation, side effect and remote onsequences has been proposed for the first. The order of study of the object of carrying out the toxicological research, the sequence of doing experiments with a choice of concrete procedure has been defined. The paravariation and adaptation to the present-day conditions of a series of procedures and methods of establishing toxicological parameters, in particular, mutagenity, harmlessness, рharmakokinetics and pharmacodynamics during chronic experiments have been carried out. During the period of carrying out the research (1991-2000) the toxicological parameters of 163 imported and home preparations have bee n studied and defined. Various methods of defining toxicity have been approved. The versatile nalysis of the received facts has been carried out depending on the pharmacological bunches and the degree of toxicity. Their LD50 have been determined during acute and chronic experiments by means of various methods of insertion. According to different classifications their class of toxicity has been defined.