Ivnyev B. Mechanisms of brain activity in physiological and pathological (Alzheimer's disease) psychic ageing

The dissertation deals with the problem of neurophysiological maintenance of the higher cortical functions in the status of physiological psychic ageing and in Alzheimer's disease. The conception of development of pathological psychic ageing is substantiated and the criteria of early diagnosis and prognosis of Alzheimer's disease are worked out on the basis of revealing the mechanisms of development of cognitive disorders in Alzheimer's disease in comparison with physiologic psychic ageing (with the use of brain evoked potentials methods and electroencephalographic mapping), pathogenetic grounding of changes in the Central Nervous System activity at the expense of disorders in the other systems of the body in case of Alzheimer's disease (immune, genetic and antioxidant-oxidant) was also established.