Chuyan E. Neuro-immuno-endocrine mechanisms of adaptation to low intensity, ultra-high frequency electromagnetic field

Establishing neuro-immuno-endocrinological mechanisms of adapta-tion in rats following an exposure to low intensity, ultra-high frequency electromagnetic radiation (UHF EMF) (?=7.1cm, density of power flow 0,1mW/cm2 ), when it is applied in an isolated manner (with no stress factor accompanying or following such exposure), preventively (when such exposure is followed by an application of a stress factor) and in combination with a stress factor. Isolated, preventive and com-bined (with stress factors of various genesis, like hypokinesia and/or injection of an antigen) application of low intensity UHF EMF modu-lates activity of all links in the neuro-immuno-endocrine system. An important role in the mechanisms of the physiological action of UHF EMF is played by the changes in the sympatoadrenal system, integra-tive activity of the brain, increased immunoreactivity and non-specific resistance, elevation of blood melatonin and cytokines (interferon and tumor necrosis factor), normalization of pro-oxidative/anti-oxidative balance in the cortex of the brain, modification of the temporal organi-zation of physiological systems and increase in the functional asymme-try. The effect that UHF EMF exerts on an intact organism may prevent negative immune and non-immune changes that are found in animals exposed to a stress factor. The anti-stress effect of UHF EMF is seen in both preventive mode and when it is combined with a stress factor. Efficiency of the anti-stress effect of UHF EMF depends on the motor asymmetry profile of animals and on the localization of its impact.