Zyablitsev S. The pathogenesis of neurohumoral regulation system function disturbances in acute period of traumatic disease in brain injuries

Subject of study - 765 white outbred male rats with brain injury (BI), 155 control animals and 20 intact animals; objective - to study the pathogenesis of neurohumoral regulation system function disturbances in acute period of traumatic disease (TD) in BI for development of new directions of their pathogenetic correction on this basis; methods - morphological, morphometrical, biochemical, radioimmunological, enzyme immunodetection, mathematical; novelty - it has been first determined that in favourable and unfavourable course of acute period of TD fundamentally different variants of hormonal balance are formed, the most important pathogenetic components of neurohormonal regulation disturbances in BI have been first showed up by the method of neuronet modelling, it has been first demonstrated that the balance between cyclic nucleotides systems in hypothalamic-pituitary system determines the type of neurohumoral systems reaction and, consequently, the course of acute period of TD, a number of common prostaglandins reaction patterns in hypothalamic-pituitary system typical for favourable and unfavourable course of acute period of TD have been first detected; results - an original experimental model for reproducing of neurohumoral regulation disturbances in acute period of TD in BI has been established, the morphological and qualimetric criteria of its reproducing have been specificated, the general directions of correction of neurohumoral regulation disturbances in BI have been developed, a series of diagnostic criteria for determining severity of the course of TD has been elaborated on the ground of quantitative and dynamic blood hormonal profile analysis, high-precision mathematical models of the course of TD acute period severity dependence on neurohumoral systems parameters and neurochemical balance of hypothalamus and hypophysis have been devised; the results have been applied in scientific and pedagogical processes of institutes of higher education in Ukraine and introduced into treatment-and-diagnosisprocess of clinics in the city of Donetsk; field of application - scientific-and-pedagogical process in general theoretic and clinical departments of institutes of higher medical education (pathological physiology, histology, pathological anatomy, physiology, traumatology, resuscitation, neurosurgery) and treatment-and-diagnosis process of resuscitation, neurosurgical and traumatological hospital departments