Object of research: adaptation processes in cows organism under action of ecological, technological and pharmacological agents. The purpose of research: to elucidate physiological mechanisms of cow adaptation to ecological and technological condition of milk industry depending on age, physiological status, productivity and to elaborate the methods of correction of immune and metabolic activity of their оrganism under conditions of different environmental factors. The methods of research and eguipment: physiological, biochemical, chysical, clinical, ecological, etological; gas-flow chromatograf "Chrom-5", spectrumphotometr SPK-115, phluorimetr, elecrophoresis devise. Theoretical and practical results: On the base of the studies of blood, milk, differrent organs and tissues of cows the physiological and biochemical mechanisms of adaptation reactions under the influence of the number of ecological and technological agents at different periods of reproductive-productive cycle have been elucidated. The influence of enteral administration of aminazine and phenazepam on blood level of main metabolites and hormons and the degree of their sorbtion and adsorbtion by mammary gland of cows after milking has been studied. The influence of mentioned preparations on main lactogenic hormones concentration in blood of primіparous during lactogenesis and adaptation to mashine milking has been shown. The schemes and doses of these supplements and preparations have been elaborated; their stimulatory influence on the intensity of metabolic processes, adaptation and reproductive ability, high productive mammary gland function has been established. The novelty: The system investigations of adaptation in cows of different age, productivity, physiological status in dependence on conditions of maintenance, milking and feeding have been conducted. The season differences of the influence of intensive technogenic impact on fatty acid composition in cows blood and milk have been elucidated. The stimulatory effect of phenazepam and aminazine on lactogenesis, reproductive function and adaptation of primaparows cows to machine milking and transgroup transmission have been established. At first time the schemes and doses of kvateren to cows at different periods of physiological and ecological adaptation have been elaborated. The stage of innovation: The schemes and doses of aminazine and phenazepam to primaparows cows during first few days after calving and training for machine milking, and also aminazine and kvaterine to adult cows with the aim of stimulation of lactogenesis, lactopoesis and adaptation to new technologic conditions of maintenance and milking have been recommended and aprobated. The brunch of use: physiology, biochemistry, pharmacology, ecology, milk husbandry, the common milk technology.
