Babadzhan V. Role of the neurohumoral activation, endothelial dysfunction and disturbances of signal transduction in progression of arterial hypertension and possibility of their medicinal correction.

. Object of investigation: arterial hypertension The aim of investigation: Clarification mechanisms of arterial hypertension, left ventricle remodeling, drug resistance by research of clinic, indexes of neurohumoral activation, endothelial dysfunction, intracellular transduction and development prognostic methods for complications and treatment. Methods of investigation: Patients with primary arterial hypertension have been included in research were provided radio-immune, immune-ensime, specrophotometric, spectrofluorimetric, electrophoretic assaies. Theoretical and practical results: As a result of work disturbances of signal intracellular transduction and activation of a chain angiotensin II - АТ1-receptor - proteinkinase II - intracellular calcium in patients with arterial hypertension has been found. Feature of endothelial dysfunction isn't so much gain vasopressor factors (endothelin, angiotensin II), how many deficiency vasodepressor factors (cGMP, bradikinin). There were developed clinical, hemodynamical, humoral criteries and prognostic algorithms for cardio-vascular complications and morbidity in patients with arterial hypertension and algorithms of antihypertensive drug treatment. The extent of introduction: Research results were inculcated in work of cardiologic clinics of Kharkov, Poltava, Institute of therapy, in the educational process of the Kharkov state medical university. Sphere of application: medicine, cardiology.