Khrypachenko I. Neurohumoral regulation and optimization of its estimation of patients with multiple organs dysfunction syndrome

Subject - rats with multiple organ dysfunction syndrome models, patients with systemic inflammatory response and multiple organs dysfunction syndrome. Aim - the perspective approach elaboration of intensive care effectiveness control in patients with multiple organs dysfunction syndrome. Methods - clinical, biochemical, enzyme immunodetection, heart rate variability analysis, statistical. It was established that the prevalence of vagal influences is accompanied to shift a cytokines balance to pro-inflammatory side. A pharmacologic stimulation of cholinergic autonomic nervous system leads to inhibition of parasympathetic influences and synthesis and release of pro-inflammatory cytokines and elevates of survival rate of experimental animals in the model of multiple organs dysfunction syndrome. The obtained results make good advisability of use the spectra analysis of heart rate variability for noninvasive neurohumoral regulation assay of critically ill patients. It was shown that the shift of regulatoryinfluences to high-frequency oscillation is the pathognomic sign for critically ill patients. It was proved, that the effectiveness of therapy is depend on the expression of systemic inflammatory response syndrome at the admission to intensive care units. The results of the investigation became the basis for mathematical model of prognosis of unfavorable outcome of the multiple organs dysfunction syndrome; forecast precision is 82.1 %.