Dubitsky L. Energy-dependent Ca2+ transporting systems of the secretory cells of the exocrine glands and mechanisms of their interaction with metal cations

The role Ca2+ transporting systems in support of functional activity of secretory cells of gastric glands and the physic-chemical mechanisms of their selective interactions whit the alkaline earth and transient metal cations have been investigated. Plasma and reticular membrane Ca2+-pumps, plasma membrane Na+-Ca2+-exchanger, mitochondrial Ca2+ transporting systems were shown to be involved in regulation of intra-cellular Ca2+ concentration in these glands. It was demonstrated, that the cations of the alkaline earth and transient metals row are cap able of competitive interaction with cation transporting centre of the secretory cells Ca2+ transporting systems. Special characteristics of interaction of metal cations with different secretory glands Ca2+ transporting systems have been analyzed. A conception of the calcium selective translocation by the energy-dependent Ca2+ transporting systems of cells, and the efficiency of inhibition of that translocation by the alkaline earth and transient metal cations has been considered.