Zayachkivska O. The role of local stress-limited system in cytoprotective mechanism of esophageal and gastric mucosa

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0507U000476

Thesis Registration Form

0507U000476.pdf

Applicant for

Specialization

  • 14.03.03 - Нормальна фізіологія

14-09-2007

Specialized Academic Board

Д 35.600.03

Essay

Dissertation is devoted to problem of the local stress-limited system (LSLS) participation in the bioregulatory mechanisms of cytoprotection in the esophageal and gastric mucosa in normal state and in study of ulcerogenesis. The key role of the LSLS endothelial-mediated, prostanoid, antioxidant components, immunotropic reactions and glycoprotein modification on formation resistance of epithelial barrier in the proximal part of digestive system was shown. It has been established new criteria of the LSLS dysfunctions that realized in combined destructive injuries in the functionally linked organs and mechanisms of influence novel potent esophagogatroprotectors.

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