Object of research: Metabolism in the organism of carp under conditions of a different intensity of invasion by botriotcephalus and in homogenates of helminths - Bothriocephalus асheilognathi; extensity, invasion intensity and index of plenty Bothriocephalus асheilognathi in carp, environmental abiotics factors; screening of matters with cestodocidal characteristic featuces. Purpose of research: Find out the features of metabolism in fishes during adaptation to the influence of a different intensity of Bothriocepha-lus асheilognathi intensity, and also in helminth of Bothriocephalus асheilognathi and to develop medical preparations for a prophylaxis and therapy of bothriocephalosis in carp. Methods of researches and equipment: physiology-biochemical, spectrometry, radiological, chromatography, parasitological, hydrochemistry, hydrobiology, morphometric, pharmacological, toxicological, citogenetical and mathematical statistics. The theoretical and practical results: Obtained results concerning metabolism in organs and tissues of this-year carp in a norm and at a different intensity invasion of Bothriocephalus асheilognathi deepen and complement scientific knowledge about the physiology-biochemical changes in the explored system: the parasite - host, and also extend the existing conception regularity of their vital functions. The conducted parasitological monitoring, concerning spread of bothriocephalosis in carps taking into account the ecological factors of water environment and intermediate hosts (Cyclops) in different natural-geographical areas of the Western region of Ukraine, has the prognosis value for prosperity of fish populations and is instrumental in organization veterinary and special measures at carp bothriocephalosis in the fish husbandries. On the basis of preclinical and clinical researches the materials the offered chart of medical treatment and prophylaxis from a bothriocephalosis carp is developed by a medicalforage mixture with "Brovadazol 20 %" and "Ribolik", which are used in the practice by the doctors of veterinary medicine in Western region of Ukraine. The novelty: The physiology-biochemical changes of lipids metabolism and correlation of separate their classes, fatty acid composition of total lipids, contents of lipid hydroperoxides products in organs and tissues of this-year carp during adaptation to a different intensity of invasion of Bothriocephalus асheilognathi was studied for the first time. Wide system research of physiology-biochemical changes of exchange of proteins total content and correlation of separate their fractions, separate free amino acids content, uric acid content, aminotransferases activity in organs and tissues of this-year carp during adaptation to different intensity of invasion of Bothriocephalus асheilognathi is conducted. A new data concerning the use of glucose, fatty acids and amino acid in the substrate providing of separate lipids classes synthesis and in energy processes are obtained, and also the intensity of albumens synthesis in organs and tissues of this-year carp at optimum physiological status in the pond fish-farming, and also at a different intensity of invasion of bothriocephalosis was obtained. The physiological features of lipids and protein metabolism and intensity of synthetic and energetical processes in the imaginal stage of cestoda Bothriocephalus асheilognathi were investigated. In different natural-geographical areas of Western region of Ukraine the features of bothriocephalosis in carp distribution are estab-lished taking into account the ecological factors of water environment and intermediate hosts - Cyclops. For the first time in Ukraine basic research of chemical compatibility of different ingredients in preparations, mass-spectra of their anthelminth actions and preclinical researches of medical preparations against a bothriocephalosis of carp was conducted. On the basis of researches results therapeutic measures against bothriocephalosis in this-year carp by application of the "Brovadazol 20 %" and the combined preparation "Ribolik" were proposed. The stage of innovation: As a result of the researches the additions to "Instruction to "Brovadazol 20 %" against a bothriocephalosis of carp" (Supplrment 2 to registration certification № 3164-02-416-05/2 from 28.02.2008) and the ratified Instructions to application of preparation of "Ribolik" production "Brovafarma" (protocol № 15 - 14/6 from 06.09.2005) were made. Obtained data were included to recommendations and instruction on diagnostics, therapy and prophylaxis of bothriocephalosis in carp. The results of researches are used in practical activity by the doctors of veterinary medicine and ichthyopathology, fish-breeder husbandries for a prophylaxis and medical treatment of bothriocephalosis in carp, applying the "Brovadazol 20 %" and "Ribolik". Sphere (field of using): physiology of man and animals, parasitology, helminthology and iсhthyopathology.
