Grigorenko A. The prognos and prophylaxis of pelvic organs prolapse at the women, surgical reabilitation

The work is devoted to determination of pathogenetic mechanisms of pelvic organs prolapse and vaginal walls prolapse at the women. Is revealed, that in a basis of disease is observed congenital not differentiated a syndrome of a dysplasia of a connective tissue with polygenic multifactor type of inheriting, which is accompanied expressed collagenolys with progressing loss of main substance, disorganization of a filamentary structure and muscle components with autoimmune aggression to collagens І, ІІ, ІІІ of types. The cellular and humoral immunodeficiencyy on a hum noise of the expressed inflammatory response of cytokines which is bound to autoimmune responses and losses of a function of support of the ligamentary apparatus of a uterus and a pelvic fundus on a hum noise hipoestrogen in pre- and a menopause is observed. Degenerative modifications in fibrillar structures are combined with an appearance of a vascular endotheliosis and disturbance of a circulation in uterine and ovary arteries. The releaser of shaping prolapse is was nonrationally the carried out first labors. At women in premenopause and a menopause joins hipoestrogenia. The developed methods of prediction, diagnostic and operative treatment have enabled to reduce relapses of prolapse (1,7 %) without repeated operative measures. Intravaginal Replaceable Hormonal Therapy by astriol (suppository Оvestin) courses for life is introduced.