Pavlov O. The prophylaxis and intensive therapy of syndrome of acute damage of a stomach in abdominal surgery (clinic-experimental research)

The 31 scientific works are protected, in which were published results of research of influence acute abdominal pathology of average heaviness on development of erosion-devastator complications. In experimental model was determined the key parts of action of the factors of algesic aggression with definition of physiological parts of consecutive damage of gastro-intestinl tract starting from reaction of sympa-thicus - adrenal system, through development of hypoxia to occurrence of endothe-lium insufficiency, that causes to development of syndrome of acute damage of a stomach. The clinical research of 180 patients with acute abdominal pathology is car-ried out. The reason was the acute gastro-intestinale hemorrhage, acute pancreatitis and acute intestinal impassability. On the basis of study of the oxygen status, acid-alkaline balance, intramucosis рН, gas structure and hemodynamics, stressful reac-tion and system inflammation response, motive - evacuator function was proved the multifarious pathophysiological process of development of syndrome of acute dam-age of a stomach with allocation of reaction sympathicus-adrenal system, hypoxia and endotoxicosis. The use of preventive strategy of intensive therapy is proved. It has allowed to decrease risk of repeated hemorrhge on 27,5% and necessity for re-peated hospitalization on 18,2% and as a result to reduce terms of stay in department of anaesthesiology and intensive therapy on 26,4% and general term of stay in hospi-tal on 8,9%