Panova T. Neurophysiological mechanisms and systems effect of the modulation of the opioid reception (experimental research).

Object - the influence of the opioid reception modulation on the functional changes аt the rats on different levels: molecular, membrane, system. Purpose – to reveal and to study a new mechanism of the opioid reception modulation on molecular and cellular levels, to examine on the system level the manifestation of this modulation, to base substantiation a new conception of the interference in the progression of the opioid-dependence. Methods – physiological, electrophysiological, neurochemical, quantumchemical, physical, statistic. Results – a new way of opioid receptors modulation with restoration of theіr properties was proposed, a expediency of to apply of discovered opioid modulation for relieving of the withdrawal of different etiologic was based. Novelty – up a new mechanism of selective modulation of the brain opioid receptors, which assisted the internalization, decreased the influence of the alkaloid ligands on opioid receptors, stimulated the synthesis of a new receptor molecules was opened was proved. The possibility of the practical using of the discovered modulation is to point for reduce the somatovegetative, paint, psychoemotional symptoms of the withdrawal (morphine and others). Data about absence of the narcotic potential of the modulator (a comenic acid), about the possibility it’s metabolism, about impossibility of the interaction with endogen opioid ligands were received. Cumulative coefficients were calculated, middle lethal doses were found for disposable and lengthy introduction. Introduction – the investigation results were introduced into educational program of physiology departments. Branch – medicine (physiology).