Dunaev A. Possibility of differential diagnostics of oxymortia as a result of sharp ischemic heart trouble, chronic narcotic and alcoholic intoxications after the morphological, biochemical and biophysical changes of auricles

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0510U000337

Applicant for

Specialization

  • 14.01.25 - Судова медицина

23-04-2010

Specialized Academic Board

Д.26.613.03

Essay

The new going is in-process offered near the decision of scientific and practically meaningful problem - to determination of criteria of differential diagnostics of oxymortia as a result of sharp ischemic heart, chronic narcotic and alcoholic intoxications trouble after the morphological, biochemical and biophysical changes of auricles. Generalization of dynamics of oxymortia is among the population of the Lugansk area for 5 years (in 2003-2007). discovered that bulk of persons which died as a result of stenocardia, chronic and alcoholic intoxications the persons of capable of working age of sex of mainly men made. The victims of the protracted abuse of opiate were mainly persons of sex of men - 82%, and among persons which died as a result of chronic intoxications an ethyl alcohol, men predominated also - 64,7%. The signs of pathomorphologic changes of auricles in the case of oxymortia as a result of sharp ischemic heart, chronic narcotic and alcoholic intoxications trouble were diminishing of specific volume of muscular fibres, fragmentation of cardiomiocytus, jumboizing their kernels, perivascular and excrescence of connecting fabric, diminishing of specific closeness of arteries. Morphological research of the leading system of heart is at an oxymortia as a result of stenocardia, narcotic, alcoholic intoxications found out dystrophic, sclerotic and necrotizing changes, the degree of expressiveness of which differed, depending on the indicated pathosiss. In subendocardial space of auricles determined fragmentaryness, microstrains of wall, increase of width of road clearance and diminishing in two times specific closeness of sinusoids capillar. The displays of complete decompensation or exhaustion of secretory function of auricle cardiomyocitus were characterize the features of oxymortia as a result of sharp ischemic heart, chronic narcotic and alcoholic intoxications trouble. By an experimental design on rats the features of changes of mithohondrial vehicle and power metabolism of myocardium of auricles were certain at an oxymortia as a result of sharp sharp coronarism, chronic narcotic and alcoholic intoxications. By biochemical research late the marker of necrosis myocardium - cardiac Troponin. And in blood of dead bodies expedience of his application is well-proven during complex verification of cardiac oxymortia. First, by the study of Laser spectrophotopolarimetry images and electric properties of myocardium of auricles were found out the biophysical criteria of differential diagnostics of oxymortia as a result of sharp ischemic heart, chronic narcotic and alcoholic intoxications trouble.

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