Pivneva T. Morphofunctional state of glial cells in experimental effects, inducing neurodegeneration.

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0510U000350

Thesis Registration Form

0510U000350.pdf

Applicant for

Specialization

  • 03.00.13 - Фізіологія людини і тварин

20-04-2010

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

The thesis is devoted to the study of the morphofunctional state of glial cells and their interaction with neurons in neurodegeneration of various origins. Under demyelination condition oligodendrocytes and astrocytes perform phagocytic function. In ischemia-reperfusion there is a correlation between the level of glial cells activation and the degree of changes in the neurons. The absence of CXCR3 receptor in microglial cells leads to disruption of their migration into a zone of damaged dendrites under the anterograde degeneration of neurons. There are functional synaptic inputs from neurons to astrocytes that have the glutamate receptors. Thus, glial cells may participate in the functioning of neural networks is the hippocampus.

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Files

aref.doc

aref.doc

Дисертація.doc

Дисертація.doc

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