Zhukova I. Toxicological characteristics of combined grain mordants Vitavax 200 FF, Vitavax 200 and Vitatiuram.

Materials of the dissertation are devoted to the study of the influence of combined grain protectants Vitavax 200 FF, Vitavax 200, Vitatiuram, and of their compounds on the organisms of laboratory and agricultural animals. Investigations were conducted with the use of complex toxicological and biochemical methods, including study of the influence of grain protectants on tissue breathing, which is the new scientific approach to the solution of this problem. For the first time in Ukraine there was scientifically based, developed and summarized aspects of toxic effect pathogenesis of combined grain protectants Vitavax 200 FF, Vitavax 200 and Vitatiuram on the organisms of rats, chickens, pigs and cattle. Theoretical fundamentals of toxicodynamics of these preparations at acute and chronic toxicosis have been formulated. There has been determined, that mentioned combined preparations have different influence on haematological characteristics, carbohydrate-energy metabolism and tissue breathing depending on the doses. New data concerning the character of acute and long-term influence of pesticide dosed, which may be founded in the feeds after grain grain-treatment, on the animal organism has been obtained. Specific and non-specific biochemical indices, the most sensitive to the action of pesticide small doses (changes of ferments of biological oxidation activity and oxidative phosphorylation intensity in rat and chicken liver mitochondrion under the influence of these pesticides) have been determined. Presented scientific statements reveal new aspects of pathogenesis of animal poisoning by Vitavax 200 FF, Vitavax 200, Vitatiuram and determine preconditions for regulation of their application in agriculture.