Babiychuk V. Mechanisms of effect of extremely low temperatures on structural and functional state of central nervous system and cardiovascular systems in animals of different age groups

Research object is structural and functional state of central nervous system and cardiovascular systems of an organism of the animals of different age groups in the norm, at obesity and rhythmic extreme cold effects. The research aim: there were reveled the mechanisms of the effect of rhythmic extremely low temperatures (-120°C) on structural and functional indices of the activity of CNS and CVS in the animals of different age groups. The research methods: To perform the studies there were used the methods of morphological, histochemical, morphometric, biochemical, electrophysiological, immune enzyme and statistical analysis. Theoretical and practical results: Application of rhythmic extreme cold effects in dynamics of aging of mammalian organism improves the efficiency of neurohumoral regulation, creates the preconditions for the increase of the resistance of aged organism to the effect of unfavorable factors. Novelty: For the first time there was substantiated the possibility of the sue of rhythmic extreme cold effects (-120°C) for the stimulation and improvement of the activity of CNS and CVS due to the activation of functioning of blood brain barrier. The implementation rate: Pre-clinical trials of the use of the method of rhythmic extreme cold effects for the correction of vegetative impairments in aged people. Application field: Practical medicine.