Kushnir I. The neurotransmitters mechanisms roles in the disorder of circadian rhythms of kidneys function

The investigation object: the mechanisms of the disturbances of the circadian rhythms of the SCN neurons and the development of the desynchronozis of the functional state of the kidneys. The investigation goal: finding out the role of the neurotransmitters mechanisms in disturbances of the circadian rhythm of excretory function of kidneys. Methods of research: pathophysiological, neuropharmacological, physiological, biochemical and statistical. Theoretical and practical value of the obtained results. the role of neuromediators (serotonine, noradrenaline, dopamine, GABA, arginin-vasopressine and melatonine) was investigated in mechanisms interneuronal interaction in SCN during the experiments on rats in vivo. It was established that the disturbances of transmitters mechanisms cause the development of desynchronozis of the function of kidneys. It was denoted that the main mechanism of disturbances of the circadian rhythm in process of the desynchronozis of the central pacemaker are the changes of the activity of GABA-ergic inhibitory system under the monoamins that leads of the disturbances of the secretion of melatonine and arginin-vasopressine. It necessary to take into consideration these results when prescribing antidepressants, and also for the diagnostics and correction of the disturbances of the circadian rhythm of the kidney function. Scientific novelty of the obtained results: for the first time it was set that the rise of the level of monoamins of the cerebry leads to the activation of GABA-ergic inhibitory system as well as during stimulation of the retino-hypothalamic tracts by the light, that causes the desynchronozis of the decrease of the secretion of melatonine and decrease of the activity of hypothalamo-pituitary-adrenal axis and augmentation of the secretion of arginin-vasopressine. The disturbances of the neurotransmitter constellation in the structures of SCN cause desynchronozis the excretory function of kidneys. The degree of implementation: the results of the research were implemented into scientific work and educational process of different departments of the pathological and normal physiology in educational institutions of Ukraine.