The object of study: the level of physical performance, state of the nitric oxide synthesis system, endothelial and cardiovascular system of young people 18-20 years with varying degrees of adaptation to physical stress. Objective: study the role of various ways of nitric oxide synthesis in the provision of adaptations of the cardiovascular system of the person to physical stress. Methods: Echocardiography, ultrasound of the heart, occlusion plethysmography, biochemical analysis, test with reactive hyperemia, a submaximal test PWC170, mathematical analysis. Theoretical and practical results, the novelty: first time conducted a comprehensive study of state of the main ways of nitric oxide synthesis, pump, systolic and diastolic heart function, the functional state of the circulatory system, vascular endothelium, physical performance of healthy young people of both sexes with different levels of physical fitness (trained and untrained persons). Established: that the high level of physical performance enhancement provided by a constitutive de novo, and reutilization NO synthesis and decreased activity of arginase and inducible de novo synthesis of NO; one of the reasons why the level of physical performance of healthy young people, which is accompanied by deterioration in the functional state of the system circulation is a significant decrease in the activity of constitutive NO-synthase, nitrate reductase activity and increased inducible NO-synthase, a close correlation between indices of physical performance and body parameters characterizing the state of the system of nitric oxide synthesis, it is proved that the stimulation of constitutive nitric oxide synthesis pathway leads ecdysterones to improve the functional state of the cardiovascular system of the body and its level of physical performance. Experimentally proved the most pronounced phases of the positive effect of ecdysterone on the level of physical capacity and participation of nitric oxide in the provision of high-functional state of the cardiovascular system of person, which is adapted to physical stress as a result of training. Scope of the work: the values obtained for the main indices of nitric oxide synthesis system in healthy people of both sexes and with different levels of physical performance can be recommended as a practical guideline values. The data of the effectiveness of stimulant effects of constitutive nitric oxide synthesis pathway at the level of physical ability can be used for sports practice for correction of functional training of athletes, as well as among those working in extreme conditions, which may also identify new trends in exercise physiology, sports and preventive medicine. The results can be used in the preparation of specialists in the field of biology, medicine, physical education and sport.
