Eshchenko Y. The role of chelatable metals in different organs cells and stress-reaction realization

Object: cellular and neurohumoral mechanisms of stress. Purpose: To examine the role of chelating metals (Zn, Mg, Cu) in the cells that contain them in the realization of stress reaction. Methods: cytochemical (studied chelating Zn, Mg, Cu staining cells with chelator-chromophores and other dyes studied secretory material associated with the chelating metals and are biologically active substances that are involved in the stress response), biochemical (the content of metals in plasma and blood glucose levels and stress hormones), sanitation (studied indicators of anthropogenic load), statistics. Results: Stress affects the content of Zn, Cu and Mg in granulocytes and blood cells Zn-detonated bodies (hippocampus, islet cells, Paneth cells, and prostate), which was reflected in the accumulation of Zn and Mg in cells under acute stress and chronic loss. Zn content changes were carried out in the same direction with Mg and back - with Cu, Zn, and as evidenced by Mg are synergistic, and Cu their antagonist. Effects of stress are regulators metallligand homeostasis. Chelators are stressors. Feature of the cytotoxic effects of chelators is damage to the cells that contain metals and impaired mechanisms metallligand homeostasis. This form of the stress response has been designated as "helatoz." It was shown that the introduction of animal cytotoxic chelators may simulate pathological conditions associated with the violation metalloligand mechanisms of homeostasis (the court in epilepsy, immune deficiency, enteropathy, endocrinopathy). Application areas: physiology, pharmacology.