Garbuzova V. Role of matrix Gla-protein system in the pathogenesis of arterial sclerotic lesions and their complications (experimental and molecular-genetic studies)

The thesis is devoted to the study of matrix Gla-protein (MGP) system role in the pathogenesis of cardiovascular diseases.It was established that blocking MGP participation in the mechanisms of protecting tissues from ectopic calcification by warfarin leads to pronounced calcification of aorta after 96 hours from the start of injecting toxic doses of vitamin D (300000 IU / kg) in rats. It was shown that the additional conditions for calcification under acute vitamin D-intoxication are created by an imbalance between pro- and anticalcinogenic enzymes of vascular wall: alkaline phosphatase activity increases by 21 %, and ecto-ATPase activity decreases 2 times as compared with controls in tissues vessels of blood. It was proved that allelic gene polymorphism of MGP system is an important factor in genetic predisposition to the development of sclerotic lesions of arteries and their complications.