The object of study is the formation of the imperatives of international knowledge transfer in the system of global scientific and technological transformations. The aim of the thesis is the scientific study of theoretical and methodological imperatives of international knowledge transfer and on this basis - developing a coherent scientific concept of technological transformation of economic systems in a global knowledge transfer. Research methods:abstract method of logical analysis, systemic-structural, economic and statistical analysis of economic-mathematical modeling and so on. Theoretical results: the scientific problem solving conceptual knowledge dialectical nature and evolution of the international transfer of knowledge through the development of scientific recommendations on the imperatives of innovation transforming economies in the global scientific and technological cooperation. Bottom Line: lies in the fact that the theoretical and methodological principles, and research findings and practical recommendations of the thesis is a scientific basis for the development of innovative strategies in the context of the country's influence modern scientific and technological transformations. Scientific novelty: the first time: the concept of the international transfer of knowledge, developed a methodology of forming the paradigm of knowledge transfer, introduced the term "innovative pasionariy"; improved: theoretical and methodological approach to innovation policy of the country, scientific and methodological basis for determining the optimal instruments of state control knowledge transfer, structural scheme of the theoretical and methodological basis of forming knowledge transfer paradigm transitology and economic, scientific and methodical approach to evaluating the effectiveness of international knowledge transfer, integrated approach to strategy development national transfer of knowledge; were further developed: the definition of the dominant trends in international scientific and technological cooperation, definition of "innovation hub"; author's definition "scientific and technological transformation", "transfer of knowledge". Degree of implementation: findings implemented: at the national level: the activity of the Verkhovna Rada Committee of Ukraine on Social Policy and Labour, the Verkhovna Rada of Ukraine on combating organized crime and corruption Committee, the Verkhovna Rada of Ukraine on budget Committee; at the regional level: the of Donetsk Regional State Administration; of Donetsk City Council Makeyevka City Council; of the Institute of Industrial Economics of NAS of Ukraine, Regional Branch of the National Institute for Strategic Studies in Donetsk, Donetsk Chamber of Commerce, Dnipropetrovsk Chamber of Commerce, Eastern Customs, at the production level: in the activity of "Creston Herenti Group Ukraine" (Kyiv), an international company Paradiesfrucht GmbH (Jahncke Group); SE "Design Bureau" South ", JSC" Ilyich Iron and Steel Works of Mariupol ", JSC" Donetsksteel "- Steel Works"; JSC "SCM", JSC "Insurance Company "Flint", and also used in the learning process of Donetsk National University. Scope: interdisciplinary.