Khytryi G. Clinical and experimental study of intensive care in hypothermic injury

The dissertation presents theoretical justification and practical solve the problem to improve treatment outcomes of hypothermic victims by means of optimization intensive care. Retrospective analysis of 723 hypothermic victims injuries were found most important risk factors and underlying causes of complications and lethal outcomes. Using discriminant analysis treatment of cold injury identified 11 leading indicators on the basis of the mathematical model to predict the severity of the condition and determine the likely prognosis of common cold injury. In conducting experimental studies of enhanced understanding of the pathogenesis of hypothermic injury in acute cold stress, resulting imbalance in the system of lipid peroxidation and antioxidant protection violation metabolism and reduction of nonspecific immune defense as well as understood pathogenesis and the opportunity of prevention and correction of hypothermic injury that caused cooling treatment, metabolic drugs of natural origin from quercetin. In a prospective analysis of 243 treat victims with a common cold injury, it was found that intensive therapy and warming of the existing methods were effective in 159 (65.4%) patients with mild and moderate severity, among patients with severe hypothermia efficacy noted in 18 (7.4%) cases. A comparative clinical and laboratory tests in patients with hypothermic injury in acute cold disease is characterized by the activation of oxidative processes, accumulation of metabolites of nitric oxide, the development of endotoxemia, regulation of cytokine imbalance, which causes deterioration of the patient with the development of complications. A study of clinical and experimental study proves the feasibility of the scheme include intensive care hypothermic injury сorvitinum metabolically active drug that enhances the therapeutic measures of 10.7%.