Nikogosian L. The pathogenetically conditioned prophylaxis of antenatal death of fetus

The purpose of research was a decline of level of obstetric and perinatal complications and dead birth by means of improvement of efficiency of pathogenetically grounded criteria of prognosis, diagnosis, prophylaxis of antenatal death of fetus. Dead birth rate in the Odessa region made up 11.7 in 1000 births. Frequency of progesteron receptor gene polymorphism at antenatal death of fetus was 57.8 %, vascular-endotelial factor of growth - 65.7 %, nitrogen oxide endotelial synthase - 67.7 %, methylentetrahydrofolatreductase - 69.6 % at the decline of progesteron and estriol level 1.2 times, increase of homocystein level - 2.8 times, decline of folic acid and cyanocobalamin concentration -2.8 and 2.3 times. Efficiency of the developed pathogenetically grounded algorithm of prophylaxis of antenatal death of fetus is proved by the decline in clinical signs of miscarriage threat 2.0 times, preeclampsia - 2.0 times, intra-uterine growth retardation of fetus - 2.9 times, placental dysfunction - 3.3 times, symptoms of gestation pyelonephritis - 1.9 times, gestation anemia -2.0 times. Homocystein level in blood of pregnant women was 1.4 times lower and folic acid - 1.4 times higher as compared to a basic group. Normalization of hormonal homeostasis was characterized by increase of progesteron concentration to 3rd trimester - 7.6 times, estriol -7.2 times, blood circulation improvement in the "mother - placenta - fetus" system - 3.0 times. Zn, Fe level in mothers' blood was 1.08; 1.4 times higher and Ca - 1.09 times lower. Zn, Fe concentration in placental tissues exceeded 1.07; 1.2 times their level as compared to a basic group, and Ca was 1.07 times lower. Frequency of ІІІ-ІV degree vaginal cleanness decreased 5.4 times.