Khaniukov O. The role of inflammation in the development and progression of atherosclerotic arteries disease of the lower extremities in patients with concomitant chronic ischemic heart disease (diagnostics, treatment, prognosis

Dissertation is devoted to the the identification of the role of chronic inflammation in the pathogenesis of atherosclerotic arteries disease of the lower extremities in patients with concomitant chronic ischemic heart disease, early diagnosis of multifocal atherosclerosis for increasing the effectiveness of treatment and improving prognosis in these patients. The role of chronic inflammation in pathogenesis of atherosclerotic arterial disease of the lower extremities in patients with multifocal atherosclerosis has been identified. It has been proved the necessity of electrocardiography, ambulatory ECG monitoring, echocardiography for early diagnosis of chronic ischemic heart disease in patients with atherosclerotic arterial disease of the lower extremities. The risk factors of multifocal atherosclerosis have been determined - dyslipidemia, arterial hypertension, smoking, obesity and diabetes mellitus type 2. It has been shown that the presence of diabetes mellutis type 2 increases the risk of cardiovascular complications in patients with atherosclerotic arterial disease of the lower extremities and multifocal atherosclerosis. It has been found out that the severity of chronic inflammation, dyslipidemia, endothelial dysfunction depends on the clinical course of the disease and the presence of diabetes mellitus type 2. The indecies to predict the risk of cardiovascular complications in patients with atherosclerotic arteries disease of the lower extremities and multifocal atherosclerosis have been identified - interleukin-6, C-reactive protein, body mass index, smoking status, "painless" walking distance, heart rate, ankle-brachial index. It has been demonsrated that the treatment of patients with atherosclerotic arterial disease of the lower extremities and multifocal atherosclerosis, which is used in clinical practice, did not significantly affect the progression of atherosclerosis. The high efficiency of the developed treatment measures in patients with atherosclerotic arterial disease of the lower extremities and multifocal atherosclerosis has been proved.