Zagorodnуy M. Metabolic medications in the treatment of arterial hypertension (clinical-experimental study)

This study shows theoretical generalizations of scientific problem of therapy of arterial hypertension and gives clinical and pathogenetic basis of using of metabolic therapy together with antihypertensive medications with the aim of increase of effectiveness of current disease. In patients with arterial hypertension stage 2, combined use of carvedilol and thiotriazoline resulted in more pronounced normalizing influence on left ventricular hypertrophy, interventricular septum thickness, left ventricle relative wall thickness, left ventricular myocardial mass, and left ventricular myocardial index in comparison with a use of basic therapy or carvedilol solely. When use of carvedilol and thiotriazoline is combined, more pronounced normalization of left ventricular isovolumetric relaxation time, left ventricular time of early diastolic flow, and also endothelium-dependent and endothelium-independent vasodilatation occur in patients with arterial hypertension. Liprilum, carvedilol, quercetin, and thiotriazoline increase membranes' hypotonic lysis resistance and normalize their permeability. Corvasan and thiotriazoline show antioxidant effect and normalize impaired lipid metabolism in the spectrum of fatty acids in spontaneously hypertensive rats. Carvedilol, quercetin, and thiotriazoline individually and combinations of carvedilol with these metabolic preparations show normalizing influence on numerical density of cardiomyocyte nuclei and RNA concentration in nuclei of cells of a myocardium in spontaneously hypertensive rats. Liprilum, carvedilol, quercetin, and thiotriazoline contribute to certain normalization of an ultrastructure of a myocardium. Combined use of liprilum and carvedilol with quercetin or thiotriazoline results in more pronounced therapeutic action on an ultrastructure of a myocardium in spontaneously hypertensive rats. Investigations in quantum-pharmacologic properties of thiotriazoline result in synthesis of 2 new chemical substances.