Shostya A. Prooxidant-antioxidant homeostasis in the pigs

Object of research - the state of prooxidant-antioxidant homeostasis of organism of different sex-age groups of pigs for the influence of physiological factors and ways of its correction. Purpose of research - to give the scientific substantiation of formation and establishing prooxidant-antioxidant homeostasis of organism of pigs depend on age, sex, breed and reproductive cycle, and to work out effective ways of increasing their productivity. Methods of research: - physiological, biochemical, morphological, histological, cytological, zootechnical, statistic. Scientific novelty: first it has been substantiated the conception of formation and establishing prooxidant-antioxidant homeostasis of organism of pigs of different age, sex, breed and the direction of the productivity. It has been proved the cyclic lability of prooxidant-antioxidant homeostasis in different tissues of sows during reproductive cycle and in tissues of foetuses depend on the period of embryogenesis. It has been found out the local-between tissues differences of the activity of enzymes of antioxidant defence and the contain of peroxidation products in the wall of uterine horns, specifically in endometrium, which are caused by phisyological state of sow and the active influence of foetus . First it has been found out direction and force of the connections between components of prooxidant-antioxidant homeostasis in tissues of maternal and foetus part of placenta of different for weight of foetuses on some stages of embryogenesis. It was obtained new data about regularities of the formation of prooxidant -antioxidant homeostasis in pig's blood depend on age and sex, which allowed to determine new approaches for performing a corrected influence on increasing the resistance of organism and the productivity of young pigs. It is given the comparative characteristic of peculiarities of the formation prooxidant-antioxidant homeostasis and cytomorphometric structure of liver, spleen, kidney, lungs and the longest muscle of back in young pigs of different breeds that essentially supplement and make deeper theoretical knowledge for working out effective methods of the directed regulation of physiological functions of organism. It has been determined new breed peculiarities spermatogenesis and the formation prooxidant-antioxidant homeostasis in young boars in the period of sex maturation, which supply the substantiation for working out methods and ways of increasing reproductive function and viability of spermatozoa. Scientific novelty of obtained results by the dissertant is conformed by 6 patents of Ukraine on a useful model. It is offered : the way of the accelerated determination of vitamin C contain and its isomers in sperm (Patent of Ukraine on a useful model № 67054A), ways of the correction of prooxidant-antioxidant homeostasis with the aim of increasing the productivity and reproductive function of young pigs ( Patents of Ukraine on useful models № 66045A, №46935), a way and it was constructed the device for intrauterus artificial insemination of sows (Patents of Ukraine on a useful model № 72852A and № 2917). These ways were inculcated into programs of feeding different production groups of pigs, and they also used for increasing the intensity of using young boars on stations and points of artificial insemination of enterprises for pork production.