Melnyk V. Course of ischemic stroke depending on the genetic polymorphism and hemostasis changes.

The scientific research is devoted to the theoretical generalization and clinical substantiation of prospects of improving the ischemic stroke diagnostics and treatment by study of the ischemic stroke genetic, hemocoagulation and hemodynamic pathogenesis aspects and to the assessment of their prognostic value in relation to patients' motor and cognitive deficiency dynamics. Based on comprehensive research, the pathogenetic value of genetic, hemostatic and hemodynamic processes and their prognostic role in the development and consequences of ischemic stroke have been specified. The frequency of different allele polymorphism distribution in LMP2 and PSMA6 proteasome gene in stroke patients has been determined for the first time, and in stroke patients within Ukrainian population - in РАІ-1 gene. The links between the most important values of coagulation, anticoagulation and fibrinolytic components of homeostasis with clinical course and acute ischemic stroke consequences within the first two weeks of diseases have been studied. The information value of coagulation, anticoagulation and fibrinolytic homeostasis components for prognosis of ischemic stroke course and consequences has been assessed. The cerebrovascular reserve state in ischemic patients has been studied as well. The morphological and functional manifestations of ischemic stroke against a background of antithrombotic therapy in experimental model of acute cerebral ischemia in rats have been investigated. The peculiarities of pathological changes in experimental cerebral ischemia against a background of antithrombotic therapy have been determined at the ultrastructural level. The optimal differential approaches for treating patients with ischemic stroke considering pathological changes of hemostasis and cerebrovascular reserve have been created.