Saturska H. Pathogenic features of development of diffuse ischemic-necrotic cardiosclerosis at various sensitivity of an organism to hypoxia.

The experimental study examined pathogenic patterns of development of diffuse ischemic-necrotic cardiosclerosis and key links of pathogenesis supporting the cardiosclerotic process depending on innate resistance to hypoxia and induction of endogenous cardioprotection. An experimental model of diffuse ischemic-necrotic cardiosclerosis was designed. It was established that the development of cardiosclerosis is accompanied by changes of concentration of bound oxyproline in blood serum and depends on the degree of oxidative, nitrooxidative stress, antioxidant defense of myocardium and individual-typological features of the organism that determine its resistance to hypoxia. Formation of diffuse cardiosclerosis is accompanied by increased concentrations of IL-1?, IL-6, TNF-?, Ig M, Ig G in the blood serum of animals; decreased concentration of IL-10, impaired neuro-mediator processes of regulation, significant deterioration of condition of microcirculation, domination of proliferative processes with maximum violations in animals with low resistance to hypoxia. The use of trimetazidine in the development of diffuse ischemic necrotic cardiosclerosis is manifested via decreased manifestations of oxidative stress, optimization of immune and cytokinе response, stabilization of humoral immune responsiveness, improvement of metabolism of connective tissue elements, indicating inhibition of cardiosclerotic process.