Klіmenko L. The integrated approach to development and validation of the procedures of analytes quantification in biological fluids for chemical and toxicological analysis.

For the first time with the purpose of improving the chemical analysis quality of extemporaneous preparations the development or modification and validation of analytical qualitative and quantitative methods for quality control of medical forms which contain salicylic acid, resorcinol, boric acid have been conducted. For the first time with the help of “efficiency curves” the sensitivity has been studied as well as the optimal conditions of chemical methods of identification of salicylic acid, resorcinol, boric acid have been determined. There has been developed a specific method of quantitative determination of salicylic acid in extemporaneous medications by spectrophotometry at the concentration 2,0 ? 10-5g/ml of salicylic acid in 70% alcohol with the addition of 1,00 ml of 1% solution of aluminum at the wavelength of 314 nm. The term of stability of ointment bases such as white soft paraffin and wool fat after opening their original packing and under conditions that they were kept in amber glass/plastic containers in pharmacies have determined throughout a year and four months respectively.