Nekhanevych O. The medical control features at persons with signs of connective tissue dysplasia at the stages of selection and sports development

The dissertation is dedicated to the problem of improving the efficiency of medical control for persons with signs of connective tissue dysplasia at the stages of selection and sports improvement through the development and justification of medical algorithm based on clinical, instrumental, functional and genetic research. The work scientifically grounded principles of differentiated approach to the distribution of people with signs of connective tissue dysplasia during selection to sports and sports improvement into groups on the basis of risk factors for cardiovascular complications, prognostic value of each dysplastic features, functional importance of small anomalies of the heart, the level of TGF-?1 polymorphism of gene COL1A1. Proved increase the value prolapse mitral valve during exercise, accompanied burden mitral regurgitation. Established decrease the contractile reserve of the left ventricle in patients with mitral valve regurgitation in that manifested a decrease in physical performance. Determined that the earliest symptoms of acute physical overexertion in people with small abnormalities of the heart is a violation of diastolic function of the heart. Proved that the level of TGF-?1 and TT genotype polymorphism rs1800012 gene COL1A1 in young athletes is a markers of dysplastic processes activity in the connective tissue.