Volyanska A. Рathogenetic ground of аdhesive process prevention in gynaecological operations in women of reproductive age (clinical-experimental research).

The aim was to increase efficiency of prevention of adhesions in gynecological operations in women of reproductive age through the development of experimentally grounded pathogenic complex of predictive and preventive treatment of tissue repair processes, taking into account the most significant pathogenesis. In the research was covered effective model of adhesion formation in experimental animals. Also was investigated the course of adhesion formation, studied structural and morphohistological markers and body system response in healthy female rats, which underwent influence of various damaging factors. Retrospective analysis determined the importance of risk factors for the formation of adhesions in women and clinical features of adhesions in the pelvic gynecological patients. A retrospective analysis set the importance of risk factors for the formation of adhesions in women and clinical features of adhesions in the pelvic gynecological patients. Research results proved the necessity of determining molecular genetic (MMR1-1607insG, COL2A1 / 6846C> A) and immunological (TNF-а, IL-6 and IL-10; CD1a and CD23) markers of susceptibility to adhesion formation in patients with a predicted adhesions. Based on the received results developed and implemented experimentally grounded and clinically proven complex of antiadhesive measures aimed at prediction, prevention and treatment of adhesions after surgery in gynecologic patients, which included usage of endosurgical low-impact equipment during operations, attenuated surgical energies, mainly ultrasonic scalpel, imposing barriers against adhesions and administration of doxycycline after operation.