Chupryna G. Multiple sclerosis: clinical and pathogenetic characteristics and therapeutic approaches based on comorbidity

The dissertation is dedicated to studying the clinical, neurophysiological, neuroimaging, neuropsychological, immunopathological manifestations of multiple sclerosis on the background of comorbid pathology, evaluation of complex treatment. The features of the manifestations of fatigue, depression, pain, cognitive impairment, sleep disorders in patients with multiple sclerosis based on comorbidity and impact of violations on the quality of life. On the basis of the study of risk factors, the analysis of magnetic resonance imaging, electroencephalography, somatosensory evoked potentials, and electroneuromyography revealed the features of development of multiple sclerosis in conditions of comorbid pathology. Based on the factors studied, a pathogenetic model of the character of the effect of comorbidity on the course of multiple sclerosis with regard to prognostic signs for clinical, psychoemotional, neurophysiological and neuroimaging indicators has been created, and it is possible to individually assess the risk of development and progression of multiple sclerosis. Efficacy and comparative analysis of the use of complex (medicaments and non-medicaments) treatment was revealed, the frequency of exacerbations decreased and the effect on the course of the disease with multiple sclerosis taking into account the comorbid pathology and heterogeneity of clinical-neurological and psychoemotional disorders, clinical, neuropsychological, neuroimaging, neuroimaging signs of disease activity.