Semenenko A. The Strategy of the Choice of Infusion Therapy for Acute Ischemic Stroke (the experimental and clinical research).

The scientific work is devoted to the development of new existing strategies of infusion therapy and the improvement them as a part of intensive care patients with acute ischemic stroke by the experimental and clinical expediency of using fluid support and justifying the effectiveness of different schemes of the infusion of this pathology. The efficiency of the colloid-hyperosmolar solution HAES-LX-5%, colloid-isoosmolar solution HES 130, hyperosmolar solution mannitol 15% and isoosmolar solution 0,9% NaCl in the model of acute ischemic disorder of the cerebral circulation was studied there. It was also established that the protective mechanisms of infusion therapy as a part of intensive therapy of acute ischemic stroke is based on the elimination: dehydration, energy deficit, endothelial dysfunction, metabolic acidosis, correction of antioxidant-oxidant system, saving cytoarchitectonics of brain, reducing edema and neyrodestruction of brain, reducing apoptosis, correction of rheology of blood. Study results of infusion therapy of acute ischemic stroke confirmed the expediency of infusion therapy as a part of intensive care patients with acute cerebral ischemia with the possibility of using combined infusion solutions, which have polyfunctional effects and can positively influence the course of acute ischemic stroke. The strategy into clinical practice with the most effective infusion support as a part of intensive care of the acute period of acute stroke was developed and introduced and it includes applying the combined infusion solution of polyfunctional properties HAES-LX-5%, which reduced the inpatient mortality accordingly: HAES-LX-5 % to 12% against 0,9% NaCl - 32% (p=0,09), mannitol 32% (p=0,09) and HES 130 - 24% (p=0,27).