Orobchenko O. Pharmaco-toxicological assessment of nanoparticles of metals (Ag, Cu, Fe and Mn dioxide) and the experimental and theoretical basis of safety regulations for use in poultry

In dissertation work illustrated parameters of improving the method of determination of inorganic elements in the feed and biological objects by the X-RAY analysis. The developed method of detection and identification of nanoparticles of metals in the feed and biological objects by the method of scanning electron microscopy for the diagnosis of possible poisoning metals in the nanoform. The results of researches of feeds and poultry products on the amount of inorganic elements which indicate that the main problems associated with an excess or shortage micronutrients, namely zinc, copper, iron, manganese and selenium. Was developed experimental model of nanocomposite metals (NcMe) containing colloidal dispersions of nanoparticles of argentum, copper, iron and manganese dioxide obtained by the method of chemical condensation with a spherical geometry, size 31-100 nm. The concentration of elements in NcMe was 0.1 mg/ml for the metal, respectively. Research has pharmaco-toxicological properties of nanoparticles of metals (Ag, Cu, Fe and Mn dioxide) as compared with the salts on laying hens are installed mechanisms of toxic effects and pharmacological effects under conditions of oral administration. Experimental and theoretical algorithms based of evaluation system of safety and biocompatibility of the nanometals and safety regulations use of the poultry industry of nanocomposite (Ag, Fe, Cu and Mn dioxide).