Kuritsina S. Diagnostics, prophylaxis and forecasting of perinatal pathology at placentation disturbances (retrochorial hematomas and anomalies of a locating of a placenta).

Dissertation work is devoted to depression of frequency of perinatal pathology at various disturbances of placentation (retrochorial hematomas and anomalies of locating) on the basis of improvement and introduction of algorithm of diagnostic, treatment-and-prophylactic and prognostic actions. New links of pathogenesis of retrochorial hematomas which consist in the leading role of disturbances of hemostasis in the form of hypocoagulation signs (depression of a prothrombin ratio, rising of quantity soluble fibrin - the monomeric complexes, activated partial tromboplastine time, augmentation of time of bleeding and time of ability of pachemia) are established; dishormonal changes ( failure of lyuteine phase in the anamnesis and depression of level of chorionic Gonadotropinum of the person and Progesteronum in early durations of gestation) and available the infectious originator in the form of mixt-infection. Interrelations between existence of retrochorial hematomas at early durations of gestation and placenta misplaced with prevalence of migration of placenta and low locating in comparison with full and incomplete placental presentation are presented. New links of a pathogenesis of placental dysfunction at women with various pathology of placentation which consist in overdue ripening of placenta are shown; existence of disturbances of hemodynamic in cord arteries, a fetus aorta that its internal carotids, in changes of the hormonal status - depression of level of not conjugated theelol, a trofoblastical glycoprotein and the protein associated with pregnancy A. The role of disturbances of vegetative nervous system (existence of depressive ranges and reactivity change) is shown in development of perinatal pathology in women with placenta misplaced. The received results allowed to prove scientifically need of improvement of algorithm of diagnostic, treatment-and-prophylactic and prognostic actions at women with retrochorial hematomas and placenta misplaced for the purpose of depression of frequency of perinatal pathology.