Kibkalo D. Clinical Biochemical Ground of Glycoproteins and Proteoglycans Metabolism Disorders in Pathogenesis and Diagnostics of Internal Diseases of Animals

The research of disorders of connective tissue metabolism in internal diseases of domestic animals – heart failure of horses, goats and dogs, poisoning of horses and cows with Cynoglossum officinale, subclinical form of ketosis of highly productive cows, polymorbid pathology (ketosis, hepatodystrophy and myocardial dystrophy) of cows, alimentary dystrophy of calves and alimentary muscular dystrophy of pigs are presented in the dissertation. Pathogenetic role of glycoproteins and proteoglycans (chondroitin sulphates and fractions of glycosaminoglycans) in the development of processes of destruction and fibrotization in internal diseases of animals on the basis of clinical results, instrumental, laboratory and histological methods was proven. The indexes of metabolism of connective tissue (glycoproteins and proteoglycans) in blood of clinically healthy domestic animals (horses, cattle, pigs, goats and dogs) of different technological groups were determined, and also their informativity in diagnostics of the most widespread internal diseases – heart failure of horses, goats and dogs, poisoning with Cynoglossum officinale of horses and cows, subclinical form of ketosis of highly productive cows, comorbid pathology of cows (ketosis, hepatodystrophy and myocardial dystrophy), alimentary dystrophy of calves and muscular and osteopathy of pigs were also experimentally and clinically grounded. The increase of glycoproteins and glycosaminoglycans in 3 and more times in case of severe internal diseases of animals is the index of critical state and unfavorable prognosis.